The key to automation of solid phase synthesis is controlling the pressure, mixing, and filtering of solvent in the reactor cells in an unattended fashion. No solid phase synthesis reactor design exceeds the elegant simplicity of J-KEM's SPS reactor. The SPS reactor uses no valves, special tubing or any device requiring operator intervention to control the retention of solvent in the reactor cell.

The SPS reactor works by applying nitrogen back pressure on the frit of the reactor cell to exactly offset the pull of gravity on the reaction solvent.  The key to the SPS reactor is the precise control ( ± 0.002 psi) of reactor pressure. Agitation of the reaction mixtures is achieved by setting the reactor pressure slightly above the "holding pressure" for vigorous mixing.

The SPS solid phase pressure regulator controls the entire reaction process. The regulator can set the pressure for 'holding' solvent at the frit or for varying degrees of bubbling. The regulator also applies vacuum through the waste port of the reactor during filtering steps. The SPS-REG regulator is controlled via its front panel keypad or by a remote PC as part of a robotic solid phase synthesis station.

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